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van Abdulqader Ahmed , Basima Sadiq Ahmed,
Volume 7, Issue 1 (3-2019)
Abstract

Background and objectives: Breast carcinoma is one of the most common malignant diseases among women worldwide. In Iraq there are noticeable elevation in incidence rates and prevalence of advanced stages of breast cancer. Cobalamin (vitamin B12) is essential micronutrient involved in one carbon metabolism and DNA methylation, which affects cancer. All of these may be change in breast cancer. The present work was designed to estimate and compare serum vitamin B12 among female breast cancer patients (60 ones) and healthy control subjects (60 ones) in Sulaimania city.
Methods: This is a case-control study conducted on sixty cases of newly diagnosed women with breast cancer, the control group include sixty healthy women. Serum vitamin B12 levels were estimated by electrochemiluminescence immunoassay (Elecsys) method. Data was analyzed using the software SPSS (Ver. 22) including frequency and percentage for categorical variables. Pearson chi-square test was used for analysis of all categorical variables.
Results: In this study we found that serum vitamin B12 levels were significantly (p=0.01) lower in breast cancer patients as compared to healthy control subject. There was no association between serum vitamin B12 levels with estrogen, progesterone, and HER2 receptor.
Conclusion: Given the results, it can be concluded that serum vitamin B12 is consistently lower among breast cancer patients. There was no association between serum vitamin B12 levels and hormones receptors status, indicating clinical implications for the interpretation of serum vitamin B12 levels. Therefore, it should be taken into consideration by physicians and cancer specialists.
 
Ahmed Abdulelah Abbas Al-Hadeethi , Farzaneh Taghian, Zaydoon Jawad Mohammed Al-Jawad, Khosro Jalali Dehkordi,
Volume 12, Issue 2 (10-2024)
Abstract

Background: Goalball is a distinctive athletic activity tailored for individuals who are blind or partially sighted. It is aimed at promoting physical activity and preventing sedentary behavior. This study explores the impact of high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on muscle damage and inflammation markers in goalball players over eight weeks.
Methods: In this semi-experimental study, 24 male goalball players were randomly assigned to one of three groups: a control group, a HIIT group, and a moderate-intensity interval training (MIIT) group. The HIIT regimen involved intermittent running for 30 seconds at 100-200% of HRR, followed by 30 seconds of active recovery at 50% HRR. The MIIT protocol consisted of 25 minutes of training at 40-50% HRR, progressing to 30-35 minutes at 60-65% HRR over the last four weeks. Data were analyzed using repeated measures ANOVA, with a significance threshold set at P-Value <0.05.
Results: The results displayed that HIIT and MIIT had a significant effect on the concentration of CK (P-Value < 0.001), LDH (P-Value < 0.001), and IL-6 (P-Value < 0.001). Also, compared to MIIT, HIIT caused a significant decrease in the concentration of CK (P-Value < 0.001), LDH (P-Value < 0.001), and IL-6 (P-Value < 0.001).
Conclusion: HIIT exerts a more pronounced effect on CK, LDH, and IL-6 concentrations than MIIT. These findings suggest that HIIT may be more effective in enhancing physiological markers in individuals with disabilities, promoting better health outcomes.

 


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