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Pacemaker pocket infection due to Mycobacterium abscessus subspecies abscessus - Case report and literature review
Maanasa Bhaskar1 , Ankita Mohanty1 , Noyal Joseph1 , Raja Selvaraj1 , Sujatha Sistla2
1- JIPMER, Puducherry
2- JIPMER, Puducherry , sujathasistla@gmail.com
Abstract:   (119 Views)
Background: Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium that can cause diverse infections in humans. The identification of the nontuberculous mycobacteria is a challenge to date due to available of limited resources. There have been case reports of device-related infections caused by them. Improper care of the cardiac implants can give rise to infections which need to be identified promptly.
Objective: To emphasize the need of early and prompt diagnosis of non-tuberculous mycobacterium infections.

Case Report  We present a case of a 69-year-old man presenting with an atrioventricular block and hence undergoes a pacemaker implant. The implant gets infected by Mycobacterium abscessus which resolves after appropriate treatment and pacemaker removal.
Conclusion: Non-tuberculous mycobacteria need to be identified and treated for the correct duration to prevent complications due to them.



 
Keywords: Nontuberculous Mycobacteria, Mycobacterium abscessus, Atrioventricular block, Pacemaker, Artificial
Full-Text [PDF 760 kb]   (41 Downloads)    
Research Article: Case Report | Subject: Microbiology
Received: 2024/03/29 | Accepted: 2025/02/23
References
1. Klug D, Wallet F, Lacroix D, Marquié C, Kouakam C, Kacet S, et al. Local symptoms at the site of pacemaker implantation indicate latent systemic infection. Heart. 2004;90(8):882-6 [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Döring M, Richter S, Hindricks G. The Diagnosis and Treatment of Pacemaker-Associated Infection. Dtsch Arztebl Int. 2018;115(26):445-52 [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Centers for Disease Control and Prevention. Nontuberculous mycobacteria (NTM) [Internet]. 2024 [cited 2024 Mar 23]. Available from: https://www.cdc.gov/hai/organisms/nontuberculous-mycobacteria.html [View at Publisher]
4. Radigan A, Jevert-Eichorn S. Rare case of pacemaker infection with Mycobacterium abscessus. BMJ Case Rep. 2019;12(9):e230100. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Moore M, Frerichs JB. An unusual acid-fast infection of the knee with subcutaneous, abscess-like lesions of the gluteal region; report of a case with a study of the organism, Mycobacterium abscessus, n. sp. J Invest Dermatol. 1953;20(2):133-69. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Villanueva A, Calderon RV, Vargas BA, Ruiz F, Aguero S, Zhang Y, et al. Report on an outbreak of postinjection abscesses due to Mycobacterium abscessus, including management with surgery and clarithromycin therapy and comparison of strains by random amplified polymorphic DNA polymerase chain reaction. Clin Infect Dis. 1997;24(6):1147-53 [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Griffith DE, Girard WM, Wallace RJ. Clinical features of pulmonary disease caused by rapidly growing mycobacteria. An analysis of 154 patients. Am Rev Respir Dis. 1993;147(5):1271-8. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Esther CR, Esserman DA, Gilligan P, Kerr A, Noone PG. Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis. J Cyst Fibros. 2010;9(2):117-23. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Radhakrishnan DK, Yau Y, Corey M, Richardson S, Chedore P, Jamieson F, et al. Non-tuberculous mycobacteria in children with cystic fibrosis: isolation, prevalence, and predictors. Pediatr Pulmonol. 2009;44(11):1100-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Sermet-Gaudelus I, Le Bourgeois M, Pierre-Audigier C, Offredo C, Guillemot D, Halley S, et al. Mycobacterium abscessus and children with cystic fibrosis. Emerg Infect Dis. 2003;9(12):1587-91. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Lee M-R, Cheng A, Lee Y-C, Yang C-Y, Lai C-C, Huang Y-T, et al. CNS infections caused by Mycobacterium abscessus complex: clinical features and antimicrobial susceptibilities of isolates. J Antimicrob Chemother. 2012;67(1):222-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Girgis DO, Karp CL, Miller D. Ocular infections caused by non-tuberculous mycobacteria: update on epidemiology and management. Clin Exp Ophthalmol. 2012;40(5):467-75. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Baker AW, Lewis SS, Alexander BD, Chen LF, Wallace RJ, Brown-Elliott BA, et al. Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. Clin Infect Dis. 2017;64(7):902-11. [View at Publisher] [DOI] [PMID] [Google Scholar]
14. Baker AW, Maziarz EK, Lewis SS, Stout JE, Anderson DJ, Smith PK, et al. Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes. Clin Infect Dis. 2021;72(7):1232-40. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Lee M-R, Sheng W-H, Hung C-C, Yu C-J, Lee L-N, Hsueh P-R, et al. Mycobacterium abscessus Complex Infections in Humans. Emerg Infect Dis. 2015;21(9):1638-46. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Thomson RM, Carter R, Tolson C, Coulter C, Huygens F, Hargreaves M. Factors associated with the isolation of Nontuberculous mycobacteria (NTM) from a large municipal water system in Brisbane, Australia. BMC Microbiol. 2013;13:89. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Leao SC, Tortoli E, Euzéby JP, Garcia MJ. Proposal that Mycobacterium massiliense and Mycobacterium bolletii be united and reclassified as Mycobacterium abscessus subsp. bolletii comb. nov., designation of Mycobacterium abscessus subsp. abscessus subsp. nov. and emended description of Mycobacterium abscessus. Int J Syst Evol Microbiol. 2011;61(Pt 9):2311-3. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Macheras E, Roux A-L, Bastian S, Cardoso Leão S, Palaci M, Sivadon-Tardy V, et al. Multilocus sequence analysis and rpoB sequencing of Mycobacterium abscessus (sensu lato) strains. J Clin Microbiol. 2011;49(2):491-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Nash KA, Brown-Elliott BA, Wallace RJ. A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. Antimicrob Agents Chemother. 2009;53(4):1367-76. [View at Publisher] [DOI] [PMID] [Google Scholar]
20. Jarlier V, Nikaido H. Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J Bacteriol. 1990;172(3):1418-23. [View at Publisher] [DOI] [PMID] [Google Scholar]
21. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175(4):367-416. [View at Publisher] [DOI] [PMID] [Google Scholar]
22. Kessler AT, Kourtis AP. Mycobacterium abscessus as a cause of pacemaker infection. Med Sci Monit. 2004;10(10):CS60-62. [View at Publisher] [PMID] [Google Scholar]
23. Cutay AM, Horowitz HW, Pooley RW, Van Horn K, Wormser GP. Infection of epicardial pacemaker wires due to Mycobacterium abscessus. Clin Infect Dis. 1998;26(2):520-1. [View at Publisher] [DOI] [PMID] [Google Scholar]
24. Dumic I, Lutwick L. Successful treatment of rapid growing mycobacterial infections with source control alone: Case series. IDCases. 2021;26:e01332. [View at Publisher] [DOI] [PMID] [Google Scholar]
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