Dr Neema Tiwari, Dr Richa Sharma, Dr Prachi Saxena,
Volume 19, Issue 4 (7-2025)
Abstract
Introduction
Nucleated red blood cells (nRBC) are immature erythrocytes whose production is thought to be driven primarily by the interplay of hypoxia and erythropoietin (EPO) synthesis..It is classified as early onset neonatal sepsis(occurring with first 24 hours of life)or late onset neonatal sepsis(occurring after 48-72 hour).
We planned the study with the aim of analysing the cause for presence of nRBCs in peripheral blood of neonates sent for routine workup in the hematology Lab of Dept of Pathology,SMSR,Sharda University
Material and Method
Retrograde analysis of 27 CBC and peripheral blood smears of neonates was done for a period of 1 month and clinical details, parameters for neonatal sepsis(NLR,PLR,LMR,IG) platelet counts and nRBC counts recorded and tabulated. For result tabulation we divided the neonatal samples into two groups 0-1 day and 2- 30 days
Results
The neonates had 17 males and 9 females. The markers for neonatal sepsis NLR ,LMR and IG were more in cases 2-30 days as compared to cases 0-1 day old. nRBCs were also raised in cases between 2-13 days old. We had 3 cases crossing nRBCs level of 200/100 WBC while 2 vases showed nRBC levels of 150/100 WBC.
Conclusion
We conclude that finding nRBCs in peripheral smear is an important indicator of neonatal stress(sepsis/jaundice/hypoxic sepsis).
