Showing 6 results for Smita
Iffat Jamal, Shuchi Smita, Ravi Bhushan Raman, Vijayanand Choudhary, Satyadeo Choubey, Kaushal Kumar,
Volume 16, Issue 6 (Special issue (Nov-Dec) 2022)
Abstract
Background and objectives: The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, a newly emergent coronavirus, first recognized in Wuhan, China in December 2019. Early identification of laboratory indicators helps in distinguishing severe patients from mild to moderate counterparts and can facilitate medical interventions, thereby lowering the mortality rate. The present study was done to evaluate the role of hematological parameters and basic coagulation parameters in the assessment of the severity of COVID-19.
Methods: This retrospective observational study was done at a tertiary care institute from May 2020 to May 2021. Hematological and coagulation profile was studied in 200 confirmed COVID-19 cases. Data related to age, gender, and clinical features were retrieved from patients’ records. Laboratory findings such as complete blood count neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and coagulation parameters in different categories were compared.
Results: The majority of patients were males (59.5%) and with mild illness (52.5%). Moderate and severe illness was present in 30% and 17.5% of cases, respectively. The frequency of anemia, leucopenia, and thrombocytopenia was 62.5%, 6%, and 5.5%, respectively. Overall neutrophilia was seen in 40.5% of cases, whereas lymphopenia was seen in 39% of cases. Coagulation parameters were also much deranged in moderate and severe cases as compared to mild cases.
Conclusion: The hematopoietic and hemostatic systems are significantly affected by COVID-19. Careful evaluation of laboratory parameters assists clinicians in formulating a tailored treatment approach and in predicting disease severity.
Iffat Jamal, Shuchismita ., Vijayanand Choudhary,
Volume 16, Issue 6 (Special issue (Nov-Dec) 2022)
Abstract
Hypocellular acute myeloid leukemia (AML) is an infrequent and challenging entity, and superinfection with coronavirus disease 2019 (COVID-19) could further complicate its diagnosis and management. It is characterized by low bone marrow cellularity, prominent cytopenias, and in many cases, clinically simulate aplastic anemia and hypoplastic myelodysplastic syndrome. We report a case of hypocellular AML-M2 in a 65-year-old male who was found to be COVID-19-positive. The cause of hypoplasia of bone marrow in such cases is still ambiguous and could be due to infiltration by blasts or co-infections. The cause of hypoplasia must be determined for proper management, which requires analysis of more such cases.
Rajendra Zope, Prachi Kate, Janice Jaison, Shalaka Saraf, Smita Bhide, Digant Gupta,
Volume 16, Issue 6 (Special issue (Nov-Dec) 2022)
Abstract
Background and objectives: In patients with coronavirus disease 2019 (COVID-19), white blood cell (WBC) abnormalities have been found worldwide with significant inter-regional differences. In the present study, we evaluated WBC parameters concerning COVID-19 positivity and severity.
Methods: In this cross-sectional study, total WBC count, absolute count of each type of WBC, neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR) were compared between 150 COVID-19 patients and 150 non-COVID-19 patients presenting with COVID-19-like symptoms. Also, COVID-19 patients were divided into severe and non-severe cases.
Results: The severity of the disease had no significant association with age or gender (p>0.05). Total WBC count, absolute neutrophil count, absolute monocyte count, and NLR were significantly lower (p<0.05), while LMR was significantly higher in COVID-19 patients compared to non-COVID-19 patients (p<0.05). Total WBC count, absolute neutrophil count, and NLR were significantly higher (p<0.05), while absolute eosinophil count and absolute lymphocyte count were significantly lower (p<0.05) in severe COVID-19 patients compared to non-severe patients.
Conclusions: Age is not a predictive factor for the severity of COVID-19. Routine WBC parameters are useful in predicting the severity of the disease in COVID-19 patients and can be used as prognostic indicators. Routine WBC parameters can also be used for repeat RT-PCR testing in COVID-19 suspected patients.
Smita Bhide, Dr. Rupali Lahane,
Volume 18, Issue 1 (Jan-Feb 2024)
Abstract
Background: Gastrointestinal tract complaints are prevalent among individuals in rural settings, encompassing all age groups. This study aimed to examine histopathological lesions in the upper gastrointestinal tract through endoscopic biopsy and determine the frequency of various upper gastrointestinal lesions in relation to age, sex, and site.
Methods: The specimens included in our study comprise endoscopic biopsies of the upper gastrointestinal tract during October 2018 to October 2020. A total of 70 biopsies from the upper gastrointestinal tract were analyzed using endoscopy. All specimens were fixed in 10% formalin and processed following routine hematoxylin and eosin (HE) examination. Special stains were employed when necessary.
Results: Among the 70 upper gastrointestinal endoscopic biopsies studied during this period, 25 (35.71%) were from the esophagus, 35 (50.0%) were from the stomach, and 10 (14.29%) were from the duodenum. Of the 70 upper gastrointestinal endoscopic biopsies, 34 displayed inflammatory lesions, while 36 exhibited neoplastic lesions. There was a male predominance among the cases examined. Non-neoplastic lesions were observed in individuals aged from the second to the fifth decade, while neoplastic lesions were more prevalent in older age groups.
Conclusion: This research highlights the stomach as the predominant location for inflammatory and neoplastic lesions in the upper gastrointestinal tract. The study reveals a notable occurrence of gastric carcinoma among malignant upper gastrointestinal lesions. Thus, early detection and management of upper gastrointestinal lesions necessitate endoscopy and subsequent histopathological evaluation.
Shuchismita ., Iffat Jamal , Vijayanand Choudhary ,
Volume 18, Issue 1 (Jan-Feb 2024)
Abstract
Plasma cell leukemia (PCL) is a rare form of plasma cell dyscrasia with 2 variants: the primary form, which occurs de novo in patients with no previous history of multiple myeloma (MM), and the secondary form, which represents a leukemic transformation in patients with a previously recognized MM. Unlike myeloma, PCL typically follows an aggressive course, and the median age at presentation is usually above 50 years. In this report, we present a case of primary PCL that manifested at 19, an exceptionally rare occurrence.
Shuchismita ., Iffat Jamal , Vijayanand Choudhary,
Volume 19, Issue 1 (4-2025)
Abstract
Hairy cell leukemia (HCL) is characterized by pancytopenia and usually associated with massive splenomegaly, however the same may not be true in the clinical settings. Here we report a case of HCL without the classical clinical feature of splenomegaly. Absence of splenomegaly doesn’t exclude he diagnosis of HCL. A careful study of morphological findings on bone marrow aspirate and biopsy followed by appropriate ancillary tests aids in correct diagnosis. A high index of suspicion is essential for diagnosing and appropriately
managing such cases. A strong suspicion on morphology in such cases is a prerequisite for reaching onto a correct diagnosis , even in absence of usual clinical presentation.
