Ebrahim Zarrinkalam, Ali Heidarianpour ,
Volume 11, Issue 5 (Sep - Oct 2017)
Abstract
ABSTRACT
Background and Objectives: Previous studies have shown that morphine dependence leads to myocardial dysfunction. In addition, apelin plays a protective role in cardiac function. The purpose of this study was to evaluate effects of morphine dependence and three models of exercise training on serum apelin level of dependent and healthy rats.
Methods: Ten healthy and 40 morphine-dependent rats were used in this study. The morphine-dependent rats were divided into four equal groups of control addicts, endurance training, strength training and concurrent training. The training exercises were carried out for eight weeks, five days a week. Serum apelin level was measured by ELISA, 72 hours after the last training session.
Results: Statistical analysis demonstrated that apelin level increased significantly in morphine-dependent rats compared to healthy controls. On the other hand, endurance and concurrent training significantly increased serum apelin level in morphine-dependent rats compared to control addicts, but strength training had not effect on serum apelin level in morphine-dependent rats.
Conclusion: Endurance and concurrent training may have cardioprotective effects on morphine-dependent rats by increasing serum apelin levels. Therefore, such training activities could be recommended to morphine-dependent patients to prevent cardiac disorders.
Keywords: Apelin, Morphine, Exercise.
Hossain Torabi, Mojtaba Eizadi, Ali Jalalvand, Ebrahim Zarrinkalam,
Volume 16, Issue 1 (Jan-Feb 2022)
Abstract
Background and objectives: Clinical evidence has demonstrated the important role of adiponectin in insulin signaling pathways in target tissue. The aim of this study was to determine effects of aerobic training on insulin sensitivity, glucose level, and adiponectin expression in subcutaneous adipose tissue of type 2 diabetic rats.
Methods: Type 2 diabetes was induced in 14 male wistar rats by intraperitoneal injection of nicotine amide and streptozotocin. The rats were randomly divided into an exercise group (n=7) and a control group (n=7). The rats in the exercise group performed aerobic training in from of treadmill running, five sessions a week, for 12 weeks. Subjects in the control group did not perform any training. Glucose level, insulin level, insulin sensitivity, and adiponectin expression in subcutaneous adipose tissue were determined at baseline and 48 hours after the lasting training session. Independent t-test was used for comparing the variables between the study groups.
Results: Aerobic training resulted in a significant increase in serum insulin (p=0.006), insulin sensitivity (p=0.003), and adiponectin expression in subcutaneous adipose tissue (p=0.037) compared with the control group. In addition, the training caused a significant decrease in fasting glucose level compared with the control group (p<0.001).
Conclusion: Based on these findings, the decrease in blood glucose may be attributed to the improvement of adiponectin-dependent insulin signaling pathways in adipose tissue in response to aerobic training. However, more cellular-molecular studies are needed to understand the mechanisms responsible for these changes.
