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Molecular detection of hepatitis delta virus in blood donors with RT-PCR
Malekpour, B., Tajbakhsh, E, Khamesipour, F, Rahimi, A,
Volume 9, Issue 2 (7-2015)
Abstract

Abstract

Background and Objective: Hepatitis delta virus is an imperfect virus with RNA and its activity depends on the presence of hepatitis B virus. This virus can lead to acute and chronic diseases in the liver. This study aimed to detect the hepatitis delta virus in blood donors with positive Hepatitis B Surface Antigens (HBsAg).

Material and Methods: In this Study, 350 serum samples were obtained from the people infected with hepatitis B blood in Transfusion organization of Shahrekord city, Iran. After extracting RNA by RNA Plus kit and making cDNA, the samples were evaluated by using RT PCR.

Results: Of 350, two samples (0.57%) were infected by HDV.

Conclusion: Low prevalence of HDV infection shows that Hepatitis B is being controlled in Shahrekord.

Keywords: Hepatitis Delta Virus, Blood Donors, Hepatitis B Surface Antigens


Prevalence of HIV, HCV, HBV in Blood Donors of Golestan Province, Iran, 2012 - 2013
Hosseini, Ma, Baniaghil, Ss, Mahmoodi, E, Bagheri Sani, Y, Dahbashi, Gh,
Volume 9, Issue 3 (9-2015)
Abstract

Abstract

Background and Objective: The donor selection and screening of blood donors for infectious factors  is the main  target of blood transfusion organization.  this study aimed at  determining the prevalence of HCV, HBV and HIV in blood donors  of  Golestan province , from 2012 to 2013.

Material and Methods: This cross-sectional study was conducted on all files of blood donors with positive lab results in  Golestan Blood Transfusion Services. The  test results, demographic characteristics and the  Prevalence of  hepatitis B and C and HIV were determined . The results were analyzed by SPSS software.

Results: The blood donors were  47,830 and 45,811 in 2012  and 2013, respectively. The  Prevalence of HBV in 2012  was%0. 299 and in  2013 %0. 284; of HCV % 0. 06  in 2012  and   % 0.05 in 2013,  and the prevalence of  both HCV and HIV totally was  0. 001percent in  two years of study. The  highest rate of positive case was among the first time donors, married and  in  those with less than  high school education  (P<0.05).

Conclusion: Regarding the high rate of positive cases  among the first-time blood donors, married and less educated, it is recommended that public media be used  for giving information to control communicable infections.

Keyword: HBV; HCV; HIV; Prevalence; Blood Donors .


Prevalence of Haemoparasites among Blood Donors in Calabar, Nigeria
Paul Inyang-Etoh, Etefia Etefia, Chinda Chime, Gabriel Ejezie,
Volume 15, Issue 6 (11-2021)
Abstract
Background and objectives: Voluntary blood donation is the main source of blood and its components globally. Blood transfusion is essential for management of various diseases but remains as one of the most important causes of disease transmission. In this study, we screened donated blood samplesfor haemoparasites in the University of Calabar Teaching Hospital, Nigeria.
Methods: This cross-sectional study was performed on 200 blood samples taken from donors who had been asymptomatic for haemoparasite infections. The blood samples were analyzed microscopically for the presence of malaria parasites using Giemsa stained thin smears and thick smears. The Knott concentration technique was used to detect microfilaria. To evaluate presence of trypanosomes, triple centrifugation was carried out and the resulting sediment was used to prepare wet and smears stained with 10% Giemsa solution.
Results: The prevalence of malaria parasites, microfilaria, and trypanosome was 38% (76/200), 5% (10/200), and nil (0/200), respectively. The prevalence of malaria infection was highest among females, individuals aged 18–25 years and those with O+ blood type. Most donors had malaria parasite density of 200–4000/µl. Microfilaria was only found in males and more common among subjects between 26 and 33 years of age as well as those with O+ blood type.
Conclusion: The findings revealed the presence of malaria and microfilaria infections and the absence of trypanosomes among blood donors in Calabar, Nigeria. This accentuates the need to screen all blood donors for haemoparasites in order to reduce the spread of the parasites and minimize its effects on the recipients.
Evaluation prevalence of Rh system major antigens (D, C, c, E, e) and their phenotypes in blood donors of Golestan province, Iran
Seyed Sadegh Baniaghil, Fardin Balochi , Alireza Ahmadi,
Volume 18, Issue 3 (5-2024)
Abstract
Background: The understanding of blood group phenotypes is currently limited to the ABO and Rh blood group systems. This study aimed to determine the frequency of Rh system antigens (D, C, c, E, e) and the phenotypes of the system in blood donors. Identifying the blood group phenotypes of donors in any population is important for improving healthcare services and better serving patients.
Methods: This descriptive study was carried out on 575 donors (Turkmen and Fars) in blood transfusion centers in Golestan Province, Iran. A cell suspension (3-5%) from each sample was prepared in normal saline and exposed to Rh system antisera using the haemagglutination technique. The Rh phenotype was then determined based on the most common genotype.
Results: For the Rh system, the antigen frequencies of D, C, c, E, and e were 87.76%, 73.6%, 72.1%, 30.83%, and 93.59%, respectively. The most common phenotypes among the Turkmen and Fars donors were R1R1, R1r, and rr, respectively, while the least common phenotypes were R2Rz and ryry. The phenotypes r'r' and ryry were not detected in the Turkmen donors, and the phenotype r''r' was not identified in the Fars donors.
Conclusion: Identifying the prevalence of blood group antigens in donors from each region is crucial for organizing negative antigen blood units, preparing compatible blood for multitransfused patients, and preventing the development of alloantibodies in these patients.
 

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