Showing 9 results for C-Reactive Protein
Marjan Vahedi, Parvin Farzanegi,
Volume 9, Issue 4 (10-2015)
Abstract
Abstract
Background and Objectives: Diabetes induced oxidative stress plays an important role in pathological damage to the heart and liver by increased production of extracellular matrix. It is thought that the use of medicinal plants, particularly Portulaca oleracea. L and regular exercise are effective. The aim of this study was to evaluate the effects of Portulaca oleracea. L consumption along with resistance training on cathepsin S, cystatin C and C-reactive protein (CRP) levels on type 2 diabetes patients.
Methods: In this semi-experimental study, 28 female type 2 diabetes patients with a mean age of 52 were randomly devided into 4 groups of control, exercise, supplement and supplement-exercise. Portulaca oleracea. L supplement was cosumed 7.5 g per day. Resistance training program was performed with a rubber band for 8 weeks, 3 days a week for 60 minutes with40-50% intensity, up to a maximum repetition. Blood samples were taken before and 48 hours after the last intervention.
Results: After eight weeks, cathepsin S, cystatin C and CRP levels in the supplementation and supplementaion-exercise group were significantly reduced (P<0.05). There were also significant differences between the groups.
Conclusion: Portulaca oleracea. L consumption and resistance training have each separate positive impacts on the cathepsin S, cystatin C and CRP levels, but the simultanous effect of Portulaca oleracea. L seed consumption and physical activity can lead to a better efficiency.
Keywords: Portulaca oleracea, resistance training, cathepsin S, cystatin C, C-reactive protein, type 2 diabetes mellitus.
Nasrin Zaer Ghodsi , Mohammad Reza Zolfaghari , Amir Fattah ,
Volume 10, Issue 1 (1-2016)
Abstract
Abstract
Background and Objective: High-intensity interval training (HIIT) is a recently proposed exercise protocol, which is time-effective. The aim of this study was to evaluate the effect of HIIT for 8 weeks on the lipid profile, C-reactive protein (CRP), fasting blood sugar (FBS) and anthropometric parameters of young women who do not exercise.
Methods: In this study, 20 young physically inactive women performed HIIT workouts for 8 weeks and 3 sessions per week. The training protocol consisted of 10-times treadmill running for 15 seconds at maximum effort and then 30 seconds of resting. Blood samples were taken while fasting, a day before and after the training and then the considered parameters were measured. Wilcoxon test was used to compare the obtained data.
Results: HIIT significantly reduced FBS, cholesterol, low-density lipoprotein, high-density lipoprotein /cholesterol ratio and CRP while increasing the HDL levels. There was a significant difference in the weight, body fat percentage, waist circumference, abdominal circumference and chest circumference of the subjects before and after the training (p <0.05).
Conclusion: HIIT can improve lipid, inflammatory and anthropometric parameters, thus it can be considered as a suitable alternative to time-consuming exercises, especially for physically inactive women who like to spend less time to achieve optimal physical wellness and body fitness.
Ma Ghaffari , Gh Mohammadzadeh , M Rezazadeh , H Rashidi ,
Volume 10, Issue 3 (5-2016)
Abstract
ABSTRACT
Background and Objective: Vitamins C and E are the two main antioxidants involved in prevention of type 2 diabetes, by reducing oxidative stress. The aim of this study was to evaluate the effects of vitamins C and E supplementation independently, on serum levels of insulin, high sensitivity C-reactive protein (hs-CRP) and resistin in people with type 2 diabetes.
Methods: In this study, 38 patients with type 2 diabetes (17 men and 21 women) received 1,000 mg/day vitamin C, and 40 patients with type 2 diabetes (21 men and 19 women) received 400 IU/day vitamin E orally. Fasting blood glucose and lipid profile were measured using enzymatic method. Hs-CRP was measured by immunoturbidimetric method, and serum insulin and resistin levels were measured by ELISA.
Results: total cholesterol, triglycerides, hs-CRP, insulin and resistin significantly were reduced after vitamin C supplementation (P<0.001). Moreover, the level of total cholesterol (P =0.018), low-density lipoprotein, triglycerides and hs-CRP significantly changed after vitamin E supplementation (P=0.001).
Conclusion: The daily intake of 1,000 mg of vitamin C and 400 IU of vitamin E may be useful in reducing diabetic complications by decreasing serum levels of hs-CRP and lipid profile in people with type 2 diabetes.
Nagmeh Alsabah Alavizadeh , Keyvan Hejazi, Tohid Mabhout Moghadam ,
Volume 12, Issue 4 (7-2018)
Abstract
ABSTRACT
Background and objectives: Visfatin is a newly characterized adipokine, which is highly expressed in visceral adipose tissue. The aim of this study was to evaluate effects of aerobic exercise training on visfatin, homocystein, C-reactive protein and lipid profile in sedentary men.
Methods: In this quasi-experimental study, 27 sedentary men were selected by convenience sampling method. The subjects were divided into a control group (n=13) and an aerobic training group (n=14). The subjects in the experimental group performed 60 minutes of aerobic exercise at 75-85% of maximum heart rate, three sessions per week for eight weeks. Data were analyzed in SPSS 16.0 (SPSS Inc., Chicago, IL, USA) using paired and independent sample t-test for comparison of means within and between groups, respectively. A P-value of less than 0.05 was considered statistically significant.
Results: The eight-week aerobic exercise training significantly reduced body weight (P=0.02), body mass index (P=0.01) and low-density lipoprotein-cholesterol (P=0.03) levels. It also caused a significant increase in the high-density-lipoprotein-cholesterol (P=0.00) and a significant decrease in visfatin levels (P=0.005). Serum homocysteine and C-reactive protein levels decreased by the end of the training program, but these changes were not statistically significant (P>0.05).
Conclusion: The eight-week aerobic exercise program could effectively improve lipid profile and visfatin levels. Therefore, this type of exercise could be recommended for prevention of cardiovascular disease and improvement of its risk factors.
Keywords: Aerobic, C-reactive protein, Exercise, Homocysteine.
Maryam Parvizifar, Mohsen Ghanbarzadeh, Saeid Shakerian, Heshmatollah Tavakol,
Volume 15, Issue 4 (7-2021)
Abstract
Background and objectives: As a chronic inflammatory airway disease, asthma can increase level of markers of inflammation and muscle damage. In this study, we aimed to evaluate the effects of short-term continuous aerobic exercise combined with vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), lactate dehydrogenase (LDH) and creatine kinase (CK) levels in asthmatic women.
Methods: In this study, 30 overweight (body mass index=26.97± 1.24 kg/m2) women with mild to moderate asthma were purposefully selected.. The subjects received a vitamin D tablet with a daily dose of 1000 IU for six weeks. The training protocol consisted of two sessions of Balke treadmill test (one session before and one session after the vitamin D supplementation). Blood samples were taken before and immediately after the exercise and before and after vitamin D supplementation. Repeated measures ANOVA was used to evaluate changes in the levels of hs-CRP, CK and LDH.
Results: The variables were not significantly affected by the exercise and vitamin D supplementation (P>0.05).
Conclusion: It seems that a single session of short-term aerobic exercise and six weeks of vitamin D supplementation do not significantly affect hs-CRP, CK and LDH levels in asthmatic women.
Alireza Ahmadi, Mahdi Ghasemian , Ali Asghar Ayatollahi, Murtadha Al-Khabori, Seyedeh Somayeh Hosseini Alarzi, Mohammad Taher Hojjati,
Volume 15, Issue 5 (9-2021)
Abstract
Background and objectives: Diagnosis glucose intolerance in pregnancy is very important in preventing maternal and fetal complications. In this study, we compared hematological and biochemical characteristics of healthy pregnant women and women with gestational diabetes mellitus (GDM) to find predisposing and prognostic variables of GDM.
Methods: In this study, 80 pregnant women (at 24-28 weeks of pregnancy) were divided into a GDM group and non-GDM group by performing oral glucose tolerance test using 75 g glucose according to the International Association of the Diabetes and Pregnancy Study Groups criteria.
Results: The mean age of women with GDM was significantly higher than those without GDM (p=0.048). Other variables including body mass index, gestational age and daily sleep duration did not differ significantly between the two groups (P>0.05). There was a significant association between family history of diabetes and incidence of GDM (p=0.040). In addition, the C-peptide level was significantly higher in pregnant women with GDM (p=0.004).
Conclusion: Considering the role of C-peptide in predicting metabolic syndrome, it is suggested to use this factor for identification of GDM patients.
Maryam Yaseri, Seyyedeh Sahereh Mortazavi Khatibani, Arvin Naeimi, Haniyeh Sadat Fayazi,
Volume 16, Issue 6 (11-2022)
Abstract
Background and objectives: In coronavirus disease 2019 (COVID-19), elevated serum levels of C-reactive protein (CRP), a marker of systemic inflammation, are commonly observed. We aimed to investigate the associations between CRP test results and clinical characteristics in patients with COVID-19.
Method: In this cross-sectional study, data from 399 patients with COVID-19 were collected through a census method. The patients were divided into a CRP-positive group (n=335) and a CRP-negative group (n=64). Demographical data, laboratory findings, clinical characteristics, and history of some underlying diseases were compared between the two groups. All analyses were carried out in SPSS (version 21).
Results: The frequency of hypertension was 40.1% among the study population, 42.4 % among CRP-positive patients, and 28.1% among CRP-negative patients. Diabetes and heart disease were the most common comorbidities among the patients. Dyspnea (60.4%), fever (52.7%), fatigue (45.4%), and dry cough (40.1%) were the most commonly observed symptoms. The mean duration of hospitalization was 8.14±6.18 days, and the mean duration of intensive care unit stay was 9.09±9.41 days. Moreover, CRP positivity was significantly associated with hypertension, immunosuppressive therapy, and higher duration of hospitalization (p<0.05).
Conclusion: Pre-existing hypertension, diabetes, and heart disease with the coincidence of some clinical symptoms are associated with higher levels of CRP in COVID-19 patients, which results in longer hospitalization.
Ashwini Suruthy, Seema Bijjaragi, G V Neethu,
Volume 16, Issue 6 (11-2022)
Abstract
Background and Objectives: The outbreak of coronavirus disease 2019 (COVID-19) has become a public health emergency. This study aimed to investigate a possible correlation between COVID-19 severity and mortality and serum levels of ferritin and C-reactive protein (CRP).
Methods: This retrospective descriptive study was conducted on 75 COVID-19 patients hospitalized in a tertiary care hospital in Central Karnataka (India) from April 2021 to June 2021. Demographic details as well as clinical and laboratory parameters were retrieved from hospital records.
Results: Of 75 patients, 50 were survivors and 25 were non-survivors. Serum ferritin levels were significantly associated with mortality (p<0.040). There was no significant association between CRP level and COVID-19 severity or mortality (p>0.05).
Conclusion: This study revealed that serum ferritin levels can be used as a prognostic marker for COVID-19 patients.
Bizav Rasheed , Beri Tawfeq,
Volume 18, Issue 6 (11-2024)
Abstract
Background: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. The disease may also affect other parts of the body, including the skin, eyes, lungs, heart, nerves, and blood. This study aimed to evaluate the effect of methotrexate on blood, liver, and renal parameters in patients with RA.
Methods: A six-month cross-sectional study was carried out on 60 consecutive patients aged 19-70 years diagnosed with RA on methotrexate treatment (10 mg) orally per week. A questionnaire was taken from participants, and laboratory tests were done on renal and liver function and complete blood count (CBC), erythrocyte sedimentation rate (ESR), glutamic oxaloacetic transaminase (SGOT or AST), glutamate pyruvate transaminase (SGPT or ALT), Creatinine, C-reactive protein (CRP), and rheumatoid factor (RF) as a follow-up to drug intake.
Results: At the end of sample collection, participants ranged in age from 19 to 70 years, with a female-to-male ratio of 1.5:1. Significant differences in platelet (PLT) levels were observed only between days 1 and 14 of the treatment (p <0.05). Similarly, SGPT levels showed significant variation between days 1 and 30 of the treatment (p <0.05). Additionally, RF levels exhibited significant differences between days 1 and 14 (p <0.01) and between days 1 and 30 of the treatment (p <0.04).
Conclusion: The recommended medication for all kinds of patients with RA is methotrexate, which has had a notable impact on blood, liver, and kidney parameters. These characteristics can serve as indicators for monitoring the medication’s effectiveness, safety, and patient follow-up.
