Mohit Kumar, Jayaprakash C S, Athira K P,
Volume 19, Issue 1 (4-2025)
Abstract
Background and objectives: Non-Hodgkin lymphoma represents a heterogenous group of lympho-proliferative malignancies with unique presentation and treatment response. This study was intended to assess the histomorphology of non-Hodgkin lymphoma subtypes and correlate with clinicopathological and immunohistochemical findings.
Methods: A retrospective study was conducted on all samples, diagnosed as non-Hodgkin lymphoma by histopathological analysis, with available immunohistochemical findings. Study was conducted in the department of pathology, for 24 months, during the period of March 2018 to February 2020. The specimens were fixed in 10 % formalin and representative sections were obtained.
Clinical details such as age, gender, location and presentation were recorded. Histopathological and immunohistochemical findings were correlated. Statistical analysis based on p value was performed.
Results: The study includes a total of 48 cases with a male predominance (56.3%). Cervical lymph node (35.4%) was the most common site. Extra nodal presentation was noted in 39.6% of the cases including stomach, testis, hard palate, para-sacral area and para-vertebral area. Diffuse large B-cell lymphoma (43.8%), followed by follicular lymphoma and mantle cell lymphoma were the most common subtypes. A statistically significant p value of 0.05 was obtained.
Conclusion: In our study, we found diffuse large B cell lymphoma (DLBCL) as the most common type of Non Hodgkin’s Lymphoma. Cervical lymph nodes were most common site of involvement. But involvement of sites like the testis and palate were also found, hence the probability of NHL in these rare sites should always to be considered.
