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Abstract Background and Objective: Helicobacter pylori (H. Pylori) infection is related to chronic gastritis, peptic ulcer, duodenal ulcer and gastric cancer. Thus, identification and treatment of the infection have a considerable importance. The aim of this study was to compare three methods of Histopathology, Culture and Rapid Urease test (RUT) in identification of H. Pylori in gastric biopsy specimens. Material and Methods: The participants were 153 patients (64 women and 89 men) suffering from digestive complaints, who referred to the endoscopy department of Shahid Beheshi Hospital in Hamadan, Iran. Three gastric biopsy samples were collected from each patient and examined by standard RUT, Histopathology and culture methods for diagnosis of H. Pylori. Results: Out of 153 patients, 69.9%, 27.4% and 2.6 % had gastritis, gastric ulcer and gastric cancer, respectively. The rate of infection with Urease test, culture and histology were identified 49.7%, 54.2%, and 89.5%, respectively. The sensitivity and specificity of the RUT result at first hour and after the first up to 24 hours were 55.4% and 80%, and 55.4% and 66/7%, respectively. The sensitivity and specificity of culture method were 60.6% and 100%, respectively. Conclusion: Based on the results, Histopathology method has a more sensitivity than both Culture method and rapid urease test for diagnosis of H. Pylori, and RUT is more specific when done in the first hour rather than after the first hour. Key words: Helicobacter pylori, rapid urease test methods, RUT, Histopathology

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ABSTRACT
Background and Objectives: Tonsils are lymphoid tissues that can be affected in various diseases. In some cases, it is necessary to remove tonsils through surgery. Although the diseases are often diagnosed by history-taking and physical examination that proceeds with surgery, histologic examination is necessary for confirmed diagnosis of malignancy. Considering the low prevalence of tonsil cancer, this study was performed to clinically examine tonsils for malignancies and evaluate the necessity of histopathological examination.
Methods: This retrospective study was conducted on 2,232 patients (aged 2-80 years) who had undergone tonsillectomy for various reasons in the city of Gorgan from 2001 to 2012. Medical history was obtained and physical examination was carried out before surgery. All the obtained samples were sent to the laboratory for histopathological examination. Finally, the collected data was analyzed.
Results: Only one case of lymphoma was found among the 2,232 patients investigated in this study. This 80-year-old woman with preoperative cervical lymphadenopathy and unilateral tonsillar enlargement went under tonsillectomy for confirmed diagnosis.
Conclusion: Considering the high frequency of tonsillectomy and the low possibility of malignancy, and the fact that malignancy is often seen in individuals with obvious clinical presentations such as in our case, it is recommended to limit referral of specimens for histological examination to highly suspicious cases through more rational decision-making and summarization of other findings.
Keywords: Hypertrophy, Malignancy, Lymphoma Pathology, Tonsillectomy

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Alireza Sobhani¹ , Hakimeh S. Sajjadi ², Touba Abbasi¹
Lymphangioma circumscriptum is a rare congenital proliferation of lymphatic vessels that may occur anywhere on the skin and mucous membranes. Based on the depth and the size of abnormal lymph vessels, these lesions are divided into two groups: the superficial vesicles are called lymphangioma circumscriptum and the more deep-seated group includes cavernous lymphangioma, cystic hygroma, and benign lymphangioendothelioma. The differential diagnosis of lymphangioma includes herpes zoster, herpes simplex, molluscum contagiosum, cutaneous melanoma, dermatitis herpetiformis, and viral warts. Herein, we report a rare case of giant cutaneous lymphangioma circumscriptum with emphasis on histopathology and differential diagnosis. Our case was a 14-year-old boy with a history of multiple, clear, pink, red, and brown vesicles protruded as a patch of wart-like growths on the flank’s skin since the 6 months of age. Histopathologic examination indicated presence of multiple thin-walled dilated lymphatic spaces in the papillary dermis lined with a single layer of endothelial cells filled with finely granular hyaline material.

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