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Showing 3 results for Pre-Eclampsia
The Role of Increased Uric Acid in Predicting Pre-eclampsia at The Gestational Age of 24-28 Weeks
Sh Aram, A Khalilian,
Volume 1, Issue 1 (4-2007)
Abstract

Abstract Background and objectives: Despite prenatal care, pre-eclampsia is still one of the most important causes of maternal and fetal mortality. There is no screening test for pre-eclampsia to be reliable and economical. One of the most accessible and easiest screening tests is blood uric acid measurement. The goal of this study is to assess the level of uric acid in high risk pregnant women a few weeks before emerging the manifestations of pre- eclampsia. Materials& Methods: In this study carried out in Isfahan medical centers, 124 pregnant women with gestational age of 24-28 weeks were selected by simple non-probability sampling. Then the subjects' uric acid were measured and considered high if it would be more than 4.5mg/dl. Results: of all the subjects, only 20 (16.1%) suffered from preeclampsia. 10 of 39(31.4%) who had high uric acid(more than 4.5mg/dl) showed pre-eclampsia.It is true for low uric acid women(68.6%), that is , the number of pre-eclampsia was ten. Conclusion: Relative risk of increased level of uric acid in preeclampsia at 24-28 weeks of gestational age was 2.2. Chi-square test showed that there is significant difference between the level of uric acid at 24-28 weeks of gestational age and the Incidence of preeclampsia. Keywords: pre-eclampsia, uric acid- high risk pregnancy


Comparison of Serum Vitamin D and Interleukin-6 Levels in Patients with Preeclampsia and Healthy Pregnant Women
Negin Rezavand, Asad Vaisi-Raygani, Firozeh Vaisi, Maryam Zangneh , Azin Hoshiar , Fariborz Bahrehmand, Amir Kiani, Gholamabass Dinarvand ,
Volume 10, Issue 4 (7-2016)
Abstract

ABSTRACT

        Background and Objective: Nutritional factors and activation of inflammatory pathways are thought to be involved in pathogenesis of preeclampsia in pregnant women. The present study aimed to compare the serum levels of vitamin D and interleukin-6 in healthy pregnant women with those of preeclampsia ones.

        Methods: This case-control study was performed on 120 healthy pregnant women and 120 women with preeclampsia referred to Imam Reza Hospital in Kermanshah. The serum levels of vitamin D and IL-6 were measured by ELISA method. The data was analyzed by SPSS software (version 20) using independent t-test, the P-value of <0.05 was considered as statistically significant.

        Results: There was no statistically significant difference between the mean level of vitamin D in the patients (37.64 ± 29.50 ng/ml) and the controls (40.06 ± 33.20 ng/ml). the serum level of IL-6 in patients with preeclampsia (21.71 ± 32.24 pg/ml) was significantly higher compared to that of  control group (15.04 ± 28.6 pg/ml) (P <0.001).

       Conclusion: Based on the findings of this study, inflammatory factors and cytokines such as IL-6 can be considered as risk factor for preeclampsia. However, more studies with larger sample sizes are required to further evaluate the association of vitamin D levels and risk of preeclampsia.

           Keywords: Pregnancy, Pre-Eclampsia, Vitamin D, Interleukin-6.


Investigating the roles of cytokines and chemokines in pregnancy-related toxemia
Adedeji Okikiade, Chidinma Kanu , Oluwadamilare Iyapo , Ololade Omitogun ,
Volume 19, Issue 1 (1-2025)
Abstract
Background: Hypertensive disorders, particularly preeclampsia (PE), complicate 2–8% of pregnancies and significantly contribute to maternal and perinatal mortality. PE disproportionately affects low-resource regions, accounting for 26% of maternal deaths in Latin America and 9% in Africa and Asia. Risk factors include extreme maternal age, chronic hypertension, obesity, diabetes, and racial disparities (Higher incidence in Black and Hispanic populations). The exact cause remains unclear, but angiogenic imbalance and immune dysregulation play key roles. This review focuses on the role of cytokines and chemokines in developing preeclampsia (PE).
Methods: A narrative review was conducted to examine studies on the immunological and vascular mechanisms of preeclampsia, with a focus on recent systematic reviews and high-impact research.
Results: The results highlighted a critical imbalance between pro-inflammatory (IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines in PE pathogenesis. Notably, reduced second-trimester IL-10 levels served as an early predictive biomarker. Endothelin-mediated vasoconstriction and Th1/Th2 immune imbalance further exacerbated endothelial dysfunction, a central feature of PE. While human and animal studies support these findings, precise mechanistic pathways remain elusive.
Conclusion: Cytokine and endothelin can serve as promising biomarkers and therapeutic targets for PE. Early IL-10 detection may improve risk prediction, but no causal links have been confirmed yet. Gaining a better understanding of these mediators could improve clinical strategies and help minimize complications. Future longitudinal research should focus on biomarkers and explore anti-inflammatory treatments for PE prevention.
 

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