Ommolbanin Younesian, Behnaz Khodabakhshi, Sara Hosseinzadeh, Seyedeh Somayeh Hosseini Alarzi, Samareh Younesian, Mojtaba Pourmomen, Mana Zakeri, Ali Hosseini, Professor Hamidreza Joshaghani,
Volume 17, Issue 5 (9-2023)
Abstract
Background: Although public health interventions have slowed the spread of SARS CoV 2 infections, the worldwide pandemic of COVID 19 is progressing. Thus, effective and safe vaccination against SARS CoV 2 is an important tool for controlling the COVID 19 pandemic. Now in the early stages of COVID 19 vaccination, vaccinated individuals are interested in using antibody tests to confirm vaccination success and estimate the time of protection. Here, we assessed anti spike IgG responses in the general population 2 weeks after the second dose of the Sputnik V vaccine.
Methods: This study included blood samples of 67 individuals without a previous SARS CoV 2 infection taken 14 days after the second dose of the Sputnik V vaccine. Anti spike IgG responses were assessed with an enzyme linked immunosorbent assay (ELISA).
Results: Anti spike IgG was detected in 55 (82.1%) of 67 samples 14 days after the second dose of the Sputnik V vaccine. Antibody levels were significantly lower in males than in females, and 9 (75%) of 12 seronegative individuals were males.
Conclusion: Vaccination resulted in detectable anti spike IgG in 82.1% of individuals, and gender may be an important factor in the humoral response.
Dr Neema Tiwari, Dr Richa Sharma, Dr Prachi Saxena,
Volume 19, Issue 4 (7-2025)
Abstract
Introduction
Nucleated red blood cells (nRBC) are immature erythrocytes whose production is thought to be driven primarily by the interplay of hypoxia and erythropoietin (EPO) synthesis..It is classified as early onset neonatal sepsis(occurring with first 24 hours of life)or late onset neonatal sepsis(occurring after 48-72 hour).
We planned the study with the aim of analysing the cause for presence of nRBCs in peripheral blood of neonates sent for routine workup in the hematology Lab of Dept of Pathology,SMSR,Sharda University
Material and Method
Retrograde analysis of 27 CBC and peripheral blood smears of neonates was done for a period of 1 month and clinical details, parameters for neonatal sepsis(NLR,PLR,LMR,IG) platelet counts and nRBC counts recorded and tabulated. For result tabulation we divided the neonatal samples into two groups 0-1 day and 2- 30 days
Results
The neonates had 17 males and 9 females. The markers for neonatal sepsis NLR ,LMR and IG were more in cases 2-30 days as compared to cases 0-1 day old. nRBCs were also raised in cases between 2-13 days old. We had 3 cases crossing nRBCs level of 200/100 WBC while 2 vases showed nRBC levels of 150/100 WBC.
Conclusion
We conclude that finding nRBCs in peripheral smear is an important indicator of neonatal stress(sepsis/jaundice/hypoxic sepsis).
