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Chronic Basophilic Leukemia; a rare myeloproliferative disorder and the role of flow cytometry for its diagnosis
Saeid Anvari1 , Setare Kheyrandish2 , Fatemeh Sotudeh3 , Hossein Mirpour Hasankiadeh4 , Korosh Khanaki3 , Esmaeil Shahabi Satlsar5
1- Regenerative Medicine, Organ Procurement and Transplantation Multi-diciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2- Hematology and Blood Banking Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran
4- Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
5- School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran , esmaeilshahabi@yahoo.com
Abstract:   (312 Views)
Background: Chronic basophilic leukemia (CBL) is a rare disorder and according to the published data, few cases have been reported as primary CBL. Morphologic findings in CBL, mostly mimic chronic eosinophilic leukemia and basophils have unusual and dysplastic morphology. Case presentation: A 47 years-old patient comes to the hospital with gastrointestinal symptoms and bloating. Complete blood count (CBC) showed leukocytosis and marked eosinophilia. After evaluating the PB smear, abnormal leukocytes with hypersegmented nuclei along with increase in eosinophils were observed. For further investigation patient was referred to hematology clinic and underwent bone marrow aspiration and biopsy. After the morphological examination, flow cytometry was performed on the aspiration sample to accurately diagnose the disease. Flow cytometric findings were in favor of chronic basophilic leukemia (CBL). Conclusions: Morphological findings is unreliable for basophils detection and for definite diagnosis, flow cytometry is reliable method to precise detection of basophils and CBL.
 
Keywords: Basophils, Chronic Basophilic Leukemia, Chronic Eosinophilic Leukemia, Flow cytometry, Myeloproliferative
Full-Text [PDF 250 kb]   (93 Downloads)    
Research Article: Case Report | Subject: Laboratory hematology
Received: 2023/03/12 | Accepted: 2023/07/17
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Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.